IL1B and neurodegenerative disease: While events that we have shown here to be linked to each other through LDs, such as IL-1β and PGE2 production, have been linked to protective mechanisms in microbial infections40–42, there are also clear examples in which exacerbated production of these mediators is linked to the development of severe diseases such as cancer, neurodegenerative diseases, atherosclerotic disease, and rheumatologic disorders43–47.