The data from the analysis revealed a repertoire of public clusters (0.786, 0.6, and 0.92% of total IgA, IgG, and IgM clusters) in the nine COVID-19 patients but not in the five HCs (0.156, 0, and 0% of total IgA, IgG, and IgM clusters) (Supplementary Fig. 4a), presumably due to the infection of SARS-CoV-2.25 In total, we identified 19 convergent IgG and 25 IgA antibodies shared by the COVID-19 patients (Supplementary Table 3, the human antibodies sequences will be provided upon request), though their SARS-CoV-2 neutralizing activity warrants future investigations. This evidence concerns the gene CD40LG and COVID-19.