As expected, the expression of FBX8 and CK were dramatically downregulated, while the Ki-67, HIF-1α, CDK4, and C-Myc were significantly upregulated in the metastatic tumor cells collected at day 28 as compared to those collected at days 7, 14, and 21 (Fig. 3a). The gene discussed is CDK4; the disease is neoplasm.