FLT1 and bronchopulmonary dysplasia: Multiple studies have demonstrated that Vegf and Vegfr2 expressions were significantly decreased, while the expression of soluble Fms-like tyrosine kinase 1 (sFlt-1), an endogenous antagonist to Vegf corresponding to a truncated form of the Vegf receptor acting as a dominant negative Vegf receptor, was significantly increased, in experimental BPD animal models, which lead to a reduction and disarrangement of the microvasculature [87,88].