ABCB1 and carcinoma: We confirmed a high efficacy of the novel transport oligonucleotide-based delivery system using MDR1 mRNA as a target and demonstrated that MDR1 mRNA targeted asON delivered by tON with three dodecyl residues significantly reduced the level of P-glycoprotein and increased the sensitivity of KB-8-5 human carcinoma cells to vinblastine.