Recent data from the PROCREATION (PROgenitor Cells Role in Restenosis and Progression of Coronary ATherosclerosis After Percutaneous Coronary Intervention) study reported that increased numbers of circulating CD34+/KDR+/CD45− cells is a predictor of major cardiovascular adverse outcome during long-term follow-up [118]. This evidence concerns the gene KDR and coronary atherosclerosis.