They describe a neural crest stem cell (NCSC)-like melanoma state that expresses some melanocyte differentiation markers, e.g., MITF and SOX10, as well as mesenchymal-like markers (e.g., FN1 and S100 calcium binding protein A16 (S100A16)), immune-related markers (interferon-induced transmembrane protein 3 (IFITM3) and major histocompatibility complex, class I, B (HLA-B)) and neural crest stem-cell makers (Nestin (NES) and MIA SH3 domain containing (MIA)). The gene discussed is HLA-B; the disease is melanoma.