TP53 and colon carcinoma: Thus, treatment of the p53-WT PROb rat colon carcinoma cell line with clinically-relevant concentrations of cisplatin (5–10 μM, 3-h exposure) caused only a minor increase in apoptosis biomarkers within 3 days; rather, such exposures induced a cytostatic/giant-cell response in the tumour cells both in vitro and in vivo in a syngeneic subcutaneous tumour model [94].