Although UVC is regarded as a poor activator of the Nrf2 response in some cell types [59], exposure of HCT116 colon carcinoma cells to UVC (20 J/m2) did cause a marked activation of Nrf2 and transcription of its downstream target heme oxygenase-1 (HO-1), likely by promoting the generation of ROS [60]. The gene discussed is HMOX1; the disease is colon carcinoma.