Loss of syndecan-1 expression has also been linked to decreased intercellular adhesion in acantholytic and spongiotic processes, which may foster blister formation in acantholytic or spongiotic dermatosis and also in pemphigus vulgaris or foliaceus [197] and thereby emphasizes an involvement of syndecans in cellular adhesion, skin homeostasis and integrity. The gene discussed is SDC1; the disease is skin disorder.