To functionally investigate the potential tumor suppressor role of ZNF554 in gliomas, we performed genome-wide expression profiling of U87 glioblastoma cells transiently overexpressing ZNF554 and found that ZNF554 overexpression induced the upregulation of 145 genes and the downregulation of 754 genes. The gene discussed is ZNF554; the disease is central nervous system cancer.