Accordingly, we aimed to examine the expression of ZNF554 both at RNA and protein levels in normal brain and adult diffuse gliomas, as well as the association of ZNF554 expression with patient survival, and to search for genome-wide transcriptomic and proteomic changes in glioblastoma cells transiently overexpressing ZNF554. To our knowledge, this is the first study that unveils the detailed expression pattern of ZNF554 in the human brain, the decreased expression of ZNF554 towards higher tumor grades, and ZNF554 as a favorable prognostic gene in adult diffuse gliomas. The gene discussed is ZNF554; the disease is neoplasm.