EZH2 and breast cancer: It is known that BPA prenatal exposure upregulates the expression of the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2), increasing trimethylation of histone 3 (H3) at lysine 27 (H3K27me3) in the mammary gland, which represents a marker of transcriptional activation typical of breast cancer cells [136].