Another study by Gregory et al., 2017, identified a role for SFRP1 in regulating the transcription factor Early Growth Response 2 (EGR2) via the TGFβ pathway [185]; the loss of SFRP1 leads to BC progression by upregulating TGFβ and thereby EGR2 [185]. The gene discussed is TGFB1; the disease is breast cancer.