It has been reported that KLF5, KLF6-SV, KLF4α and KLF7 have a role in tumor progression, epithelial to mesenchymal transition (EMT) and metastasis [61,62,63], whereas KLF2, KLF6, KLF4 and KLF15 inhibit proliferation, metastasis and cell cycle in BC [62,64]. The gene discussed is KLF5; the disease is breast cancer.