The differences in proteomic composition that result from this selective adjustment of blood coagulation have already been extensively characterized by our group, showing that, while HPP has a comparable concentration of the proangiogenic factor vascular endothelial growth factor (VEGF) to HPS, it has a lower concentration of the platelet-derived angiogenic inhibitors thrombospondin-1 (TSP-1) and platelet factor-4 (PF-4) [37,39]. The gene discussed is VEGFA; the disease is Hermansky-Pudlak syndrome.