On the other hand, clopidogrel inhibits the angiogenesis of gastric ulcer healing at least partially through inhibition of the VEGF-VEGFR2-ERK signal transduction pathway and, also, inhibits VEGF-stimulated HUVEC proliferation via the downregulation of VEGFR-2 and pERK [68]. This evidence concerns the gene EIF2AK3 and gastric ulcer.