Examination of the platelet-derived angiogenic inhibitors TSP-1 and PF-4 in these secretomes did show a significantly lower concentration in HPP compared to HPS (p < 0.05), in agreement with our previous data (Figure 3B,C), while this difference was present with or without T1D/T2D (Figure 4B,C), except for T1D subjects who had similar levels of TSP-1 in HPP and HPS. Here, THBS1 is linked to type 2 diabetes mellitus.