CD4 and chronic pancreatitis: The systemic alteration of CD4+ T-lymphocyte and B-lymphocytes during the early phase of AP, indicating persistent MOF [29], and increased circulating levels of CD4+ T-cell cytokines such as IL22 [55], TGFβ and IL10 during acute and chronic pancreatitis, establishes the utility of adaptive immune effectors as the predictors of disease severity in the context of different etiological contributors.