IL1B and congenital rubella syndrome: In more severe cases, the disease is characterized by interstitial pneumonia with alveolar damage, which can lead to cytokine release syndrome (CRS) associated with massive production of pro-inflammatory cytokines and chemokines (IFN-α, IFN-β, IL-1β, IL-6, IL7, IL-8, IL-2, TNF, CXCL10, CCL2) within approximately 7 days or later of symptom onset [114,115].