SJS/TEN as the most severe type of dermatologic AEs associated with EGFR-TKIs has been reported predominantly from Asian countries, with afatinib-associated SJS reported from Germany and Japan [10,11], osimertinib-associated SJS from Taiwan [7] and TEN associated with gefitinib [9] and osimertinib [8] from China (Table 1). The gene discussed is EGFR; the disease is toxic epidermal necrolysis.