In their cross-sectional study, Bergen et al., used a new mass spectrometry-based assay to show that circulating myostatin, acting as a homeostatic regulator of muscle mass in males, could be found in the highest concentration in young men, and decreased with age, while in women, it increased as a function of age, acting as a possible mediator of sarcopenia [85]. This evidence concerns the gene MSTN and sarcopenia.