Despite new studies on animals demonstrating an anti-hypertrophic and anti-autophagic effect of myostatin on a heart (mediated by 5’AMP-activated protein kinase (AMPK)/mTOR and miRNA-128/PPARγ/NF-κB pathways) [177], as well as its ability to induce interstitial fibrosis in the myocardium via transforming growth factor beta-activated kinase 1 (TAK1) and p38 pathway [178], more research is needed in order to fully understand its role in the pathophysiology of heart disorders. This evidence concerns the gene MAP3K7 and heart disorder.