In summary, CD36 mediates apoptosis of tubular cells induced by hyperglycemia, glycated albumin, FAs, or oxHDL, while hyperglycemia, albumin, AOPPs, or oxLDL promote interstitial fibrosis by EMT, the secretion of ECM proteins, and TGF-β1 and inflammation. The gene discussed is CD36; the disease is Hyperglycemia.