CD36 and type 2 diabetes mellitus: In contrast, Nagao et al. [12] found that CD36 overexpression present in the islets of obese patients with T2DM, but not those without T2DM, contributes to defective insulin exocytosis with the reduction of exocytotic protein levels and subsequent impairment of granule docking, which is associated with the reduction of the first-phase insulin secretion in T2DM.