Fabry Disease (FD) (OMIM #300644) is an X-linked lysosomal storage disorder caused by the deficiency of the enzyme alpha-galactosidase A. It results in progressive intracellular deposition of globotriaosylceramide (GB3) and related neutral glycosphingolipids in multiple organ systems, including skin, kidneys, vascular endothelium, ganglion cells of the peripheral nervous system, and heart [88]. This evidence concerns the gene GLA and Fabry disease.