We also performed NOD-specific super enhancer analysis using H3K27ac ChIP-Seq signals in NOD ES cells [36] and found a subset of top super enhancers, Pcmtd1, CD16 and Igfbp2, which were previously implicated in diabetes genome-wide association studies (GWAS) [37,38] (Figure 4d). Here, IGFBP2 is linked to diabetes mellitus.