HLA-C and neoplasm: In this study, we named the functional domains as the immune escape-initiating domains because significant alterations in genes or gene expression in these domains at the early stage of the cancer-immunity cycle resulted in significant impacts on tumor-T cell interactions (i.e., immune escape points) due to unsuccessful binding between neoantigenic peptide-MHC and TCR, including immune evasion, which enabled uncontrolled proliferation of tumor cells.