Conversely, the exposure of adipocytes to pure or mixed beta 1 and beta 2 adrenergic receptor agonists such as salbutamol, terbutaline, isoprenaline and dobutamine produced a #3T3-CM that induced a resistance of tumor cells to lapatinib-mediated cytotoxicity at least as strong as #3T3-CM from adipocytes alone. Here, PSMB6 is linked to neoplasm.