CD4 and androgen insensitivity syndrome: Thus, we speculate that abnormal upregulation of sIL-2Rα is involved in the imbalance between neuroprotective CD4+ T cell subsets (Th2 and Treg) and neurotoxic CD4+ T cell subsets (Th1 and Th17) and promotes neuroinflammation and poor prognosis after AIS.