HMGB1 is reported to induce signalling via the RAGE receptor and the HMGB1/RAGE/cathepsin B signalling pathway, which activates NLRP3-dependent coronary endothelial cell pyroptosis and thus plays an important role in the endothelial damage that occurs in Kawasaki disease [39]. The gene discussed is HMGB1; the disease is Kawasaki disease.