ENO1 and neoplasm: In this study, we found that SNP rs140618127 in LOC144680 contained a binding site for miR-539-5p, and the binding between miR-539-5p and LOC146880 resulted in declined phosphorylation of an oncogene, ENO1, which was found to be a downstream target of LOC146880. Furthermore, the reduced phosphorylation of ENO1 led to decreased phosphorylation of PI3K and Akt, which was linked to the decline in tumor cell proliferation and progress.