In this study, we found that SNP rs140618127 in LOC144680 contained a binding site for miR-539-5p, and the binding between miR-539-5p and LOC146880 resulted in declined phosphorylation of an oncogene, ENO1, which was found to be a downstream target of LOC146880. Furthermore, the reduced phosphorylation of ENO1 led to decreased phosphorylation of PI3K and Akt, which was linked to the decline in tumor cell proliferation and progress. This evidence concerns the gene AKT1 and neoplasm.