ENO1 and neoplasm: To explore the molecular mechanism of SNP rs140618127 in NSCLC development and progression, we evaluated that the biological consequence of LOC146880 and miR-539-5p interaction, and found that the microRNA behaved like a tumor suppressor [11], which prevented LOC146880 from interacting with protein ENO1, an oncogene product [12], reducing its phosphorylation.