BUB1, which is encoded by BUB1B, has been known as a checkpoint for proper chromosome segregation, the abnormal expression of BUB1 has been reported to associate with poor survival and metastasis in various tumors including colorectal cancer, gastric cancer, bladder cancer, hepatocellular carcinoma and so on [35, 43–45]. This evidence concerns the gene BUB1 and colorectal cancer.