TNFAIP8 and acute myeloid leukemia: To investigate whether the effect of TNFAIP8 on AML cells is mediated by ERK signaling, we treated AML cells, K562 and HL60, transduced with Flag-tagged TNFAIP8 or control vector with ERK inhibitor SCH772984, and examined their proliferation and chemotherapeutics-aroused apoptosis.