Immunoblotting analysis confirmed that TNFAIP8 knockdown suppressed phosphorylation of ERK and MEK in AML chemoresistant cells after 8-h treatment of doxorubicin, while TNFAIP8 overexpression increased ERK and MEK phosphorylation in AML chemosensitive cells (Fig. 5a-b). The gene discussed is MAP2K7; the disease is acute myeloid leukemia.