Tumor necrosis factor α-induced protein 8 (TNFAIP8), also called SCC-S2, GG2-1, MDC-3.13, NDED and OXI-α, containing a death effector domain, was first found in human head and neck squamous cell carcinoma [17]. This evidence concerns the gene TNFAIP8 and head and neck squamous cell carcinoma.