In these cell lines, the rosemary extracts also increased the expression of BAX, cleaved caspase-3, CHOP, and IRE1α, in a mechanism similar to our findings [68] Finally, the Zyflamend component holy basil has also shown promise in pancreatic cancer research as it inhibited tumorigenesis in both murine and in vitro models and promoted apoptosis [69]. Here, ERN1 is linked to familial pancreatic carcinoma.