Endothelial pyroptosis is a vital mechanism of vascular endothelial injury in sepsis, and this process leads to the release of a plethora of pro-inflammatory cytokines, such as IL-1β and LDH, and destroys the endothelium barrier, eventually leading to septic shock and multiple organ failure [13, 14, 28]. The gene discussed is IL1B; the disease is Multiple Organ Failure.