Although a small amount of evidence has revealed that HGF exerts antiapoptotic and cytoprotective effects in various epithelial and endothelial cells, e.g., HGF attenuates LPS-derived endothelial apoptosis [15], modulates chemotherapeutic agents induced autophagy and necrosis [16], whether HGF protects the vascular endothelium against pyroptosis in sepsis remains unknown. The gene discussed is HGF; the disease is Sepsis.