A3 proteinuria conferred the highest adjusted OR across all the diseases but differentiating factors for rapid progression included lower Hb in diabetic nephropathy (OR 0.96, 95% CI 0.93–0.98, p = 0.002), lower albumin in glomerulonephritis (OR 0.89, 95% CI 0.82–0.97, p = 0.005), and older age in hypertensive nephropathy (OR 1.06, 95% CI 1.01–1.11, p = 0.023). The gene discussed is GSTM1; the disease is glomerulonephritis.