The results of Western blotting analysis showed that the levels of BMP4 and Smad4 proteins in myocardial tissues of the offspring in the SCH groups were significantly lower than that in the Sham group, while L-T4 treatment significantly increased the expression of BMP4 and Smad4 proteins in both LT4-E10 and LT4-E13 groups (Fig. 6c-d, p < 0.05). This evidence concerns the gene SMAD4 and spindle cell hemangioma.