We found a meaningful relationship between infection with vacA and cagA positive strains of H. pylori and development to peptic ulcer (OR: 1.63, 1.39–1.91; Q-value: 12.15; I2: 0.00; p value: 0.00 and Egger’s regression: 0.53) (Fig. 5). Here, S100A8 is linked to peptic ulcer disease.