IL10RB and inflammatory bowel disease: In a follow-up study, Forbester et al. investigated the role of IL-22 in priming the antimicrobial defense of the human intestine to counteract S. Typhimurium infection.27 Organoids were generated using stem cells from a patient with infantile inflammatory bowel disease, harboring a loss-of-function mutation in the IL-10Rβ gene that encodes IL-10R2.