CAT and Crohn disease: de LeBlanc and colleagues proved that engineered Lactobacillus casei BL23 strains producing CAT were able to prevent or decrease the severity of intestinal pathologies caused by ROS.82 The same team later discovered that engineered L. casei BL23 strains producing either CAT or SOD promoted the recovery of initial weight loss in mice with trinitrobenzenesulfonic acid-induced Crohn’s disease, increased enzymatic activities in the gut, and reduced the extent of intestinal inflammation.83