PLS3 and neoplasm: Wong et al described hypomethylation‐mediated overexpression of PLS3, GATA3 and TWIST3. 18GATA3 overexpression in CTCL was confirmed by Kamijo et al19 The study showed that hypomethylation‐mediated GATA6 overexpression promotes tumour progression via overexpression of CD137L that together with CD137 activates pathways leading to cell proliferation, tumour survival, growth and migration.