CDH1 and lip and oral cavity carcinoma: In oral cancer, low E-cadherin expression appears to associate with a poor prognosis.16 In addition, high-grade OPSCC has a high recurrence rate.45 In HPV-negative OPSCC, García-Pedrero et al.46 showed that low membranous β-catenin and E-cadherin expression was associated with a poorer overall survival.