Notably, The Cancer Genome Atlas Consortium (TCGA) have identified molecular subclasses within GBM and core molecular pathways, including receptor tyrosine kinase (RTK)/Ras/phosphoinositide 3‐kinase (PI3K), Rb, and p53 that are frequently dysregulated.2, 4, 9, 10, 11, 12. This evidence concerns the gene RB1 and glioblastoma.