In a mouse model of osteoporosis induced by oestrogen deficiency following bilateral ovariectomy, EZH2 protein and RNA levels were found to be elevated in BMSC isolated from osteoporotic bone samples, with EZH2 and H3K27me3 being highly enriched on promoters of Wnt1, Wnt6 and Wnt10a leading to repression of these bone promoting genes [21] and promoting adipogenesis. This evidence concerns the gene EZH2 and osteoporosis.