Anxiety: increased as [CO2] increased distance traveled: increased as [CO2] increased  Heart rate: ND or increased as [CO2] increased  Blood pressure: ND or decreased as [CO2] increased  Plasma ACTH: reduced with pentobarb LOP: ND or faster as [CO2] increased  Time to death: ND or faster as [CO2] increased. Here, POMC is linked to Anxiety.