IFNG and neoplasm: IFN-γ produced by T cells upon tumor antigen recognition signals through IFN-γ receptor and consequently results in expression of IFN-γ stimulated genes by inducing activation of Janus kinase JAK1/2, and phosphorylation of the signal transducers and activators of transcription (STAT) (Bach et al., 1997; Platanias, 2005).