Consistent with this, we also observed a 45% increase in proportion of Selplg–/– KIT+ blasts actively cycling (phase S-G2-M of cell cycle with genomic DNA > 2n by Hoechst33342 nuclear staining) compared to WT KIT+ AML blasts (Figure 4D, bottom panel). The gene discussed is KIT; the disease is acute myeloid leukemia.