SELPLG and acute myeloid leukemia: In addition, a higher level of circulating AML blasts in whole blood was also observed in hosts of Selplg–/– AML (8.8 ± 3.15 million circulating AML blasts per mouse) compared to hosts of WT AML (2.3 ± 1.26 million circulating AML blasts) (p = 0.0009, Figure 4E).