KMT2A and acute myeloid leukemia: Indeed, AML is a highly heterogeneous disease, that can be caused by variety of chromosomic rearrangements with translocations leading to production of chimeric proteins (such as AML1-ETO or MLL fusion proteins) and/or somatic mutations such as FLT3-ITD or NMP1 (De Kouchkovsky and Abdul-Hay, 2016).