None of the other adhesion molecules tested promoted AML cell survival (Figure 2A and Supplementary Figure 2) confirming the specificity of E-selectin as an adhesion molecule promoting survival signaling in human AML cell lines in vitro. Together these data suggest the expression of CD162 on AML cells is important for E-selectin-mediated chemo-resistance in our in vitro model – providing the first evidence of a potential role for CD162 in mediating AML chemo-resistance. The gene discussed is SELPLG; the disease is acute myeloid leukemia.