As an epigenetic regulator and transcription factor, BRD4, along with its chemical inhibitor JQ1, is strongly implicated in regulation of cell proliferation, survival and tumor growth in KRAS mutated NSCLC in a c-Myc-dependent manner (Shimamura et al., 2013; Bouillez et al., 2016). This evidence concerns the gene KRAS and non-small cell lung carcinoma.