KRAS and neoplasm: While the chemical inhibitor-based targeting of this mutational KRAS is under clinical trial investigation (Yuan et al., 2018), there remains a lack of an effective therapeutic strategy for treating NSCLC tumors carrying non G/C substitutions of KRAS or with co-activation of other oncogenes or tumor suppressors (Yuan et al., 2018; Skoulidis and Heymach, 2019).