Gene set enrichment analysis revealed that several tumor hallmarks were enriched in the high-risk subgroup, such as epithelial–mesenchymal transition, the reactive oxygen species pathway, P13K-AKT-MTOR signaling, inflammatory response, KRAS signaling, complement, IL2-STAT5 signaling, glycolysis and MTORC1 signaling (Figure 5D) and so on. This evidence concerns the gene AKT1 and neoplasm.