It has been reported that LINC00665 increases the malignancy of hepatocellular carcinoma by activating the protein kinase R (PKR)/nuclear factor (NF)-κB pathway (Ding et al., 2020) and induce gastric cancer progression by activating the Wnt signaling pathway (Yang G. et al., 2014). Here, LINC00665 is linked to hepatocellular carcinoma.