For instance, HOXA11-AS is reported to be a cell cycle-related lncRNA as well as a biomarker of glioma patients (Wang et al., 2016; Se et al., 2017); MALAT1 was a suppressor of glioma by downregulating MMP2 and devitalizing ERK/MAPK signaling (Han et al., 2016); and knockdown of DANCR could inhibit glioma cell growth and invasion through downregulating miR-135a-5p/BMI1 axis (Feng et al., 2020). Here, MMP2 is linked to central nervous system cancer.