PLG and cancer: For example, FoxO3a inhibits cancer cell progression from G1 to S phase by up-regulating cell cycle inhibitory proteins p21 and p27 (Bu et al., 2016), whereas angiostatin and thrombospondin, which are highly expressed in the hAM-MSCs, can increase the number of cancer cells in G1 phase and decrease the number of cells in G2/M phase and S phase and, as a result, inhibit their further proliferation (Ramasamy et al., 2007; Rolfo et al., 2014; Di Germanio et al., 2016; Modaresifar et al., 2017).