AKT1 and neoplasm: Akt promotes Forkhead box O (FoxO) 3a, which regulates transcription of several genes that participate in tumor apoptosis cell cycle progression, DNA repair, oxidative stress resistance, and other cellular functions (Chen J. et al., 2010; Chen Q. et al., 2010; Yang et al., 2010; Lam et al., 2012; Ruvolo, 2012; Shukla et al., 2013, 2014; Wang et al., 2013; Zhang Q. et al., 2020).