Treatment with ivacaftor alone or in combination with lumacaftor showed a significant decrease in Aspergillus-induced ROS production by PMN (−93.8 ± 4.5 and −85.9 ± 5.6%, respectively) and PBMC (−96.4 ± 2.2 and −94.7 ± 3.2%, respectively) from CF patients with other CFTR mutations (non F508-del, non G551D) (Figure 3). Here, CFTR is linked to cystic fibrosis.