Acebilustat, currently in phase I/II trials in CF patients, is a leukotriene A4 hydrolase (LTA4H) inhibitor, inhibiting the production of the intracellular lipid mediator leukotriene B4 (LTB4) (Bhatt et al., 2017; Elborn et al., 2017a,b, 2018). This evidence concerns the gene LTA4H and cystic fibrosis.