MUC1 has also previously been shown to be a metabolic master regulator in cancer cells in which it regulated metabolism flux at multiple levels, including: (i) directly regulating expression of metabolic genes by acting as co-transcriptional factor; (ii) regulating metabolic functions by modulating the activity/stability of enzymes and transcription factors; and (iii) modulating levels of reactive oxygen species and metabolite flux (Pitroda et al., 2009; Mehla and Singh, 2014). The gene discussed is MUC1; the disease is cancer.