Second, the plasma ADAMTS13 level is related to liver cirrhosis (Uemura et al., 2008); the METAVIR scoring system (liver biopsy, F0~F3) is the gold standard; only some patients subjected to liver biopsy, although all patients underwent liver stiffness assessed via RTE, and RTE is non-invasive and accurately stage hepatic fibrosis (Chen et al., 2017). The gene discussed is ADAMTS13; the disease is cirrhosis of liver.