Although the exact oncogenic effect of EWSR1-VGLL1 is still obscure, given the oncogenic roles of EWSR1 fusion genes, such as EWSR1-FLI1 and EWSR1-ERG, in Ewing sarcoma (47), EWSR1-VGLL1 likely has a potential to act as an oncogene. Here, VGLL1 is linked to Ewing sarcoma.