To date, there are two main drug types for cancer targeted therapy based on high EGFR expression: EGFR monoclonal antibodies, including the currently approved cetuximab, panitumumab, nimotuzumab, and necitumumab, and tyrosine kinase inhibitors, including afatinib, erlotinib, gefitinib, and osimertinib, which have been approved for marketing. This evidence concerns the gene EGFR and cancer.