RB1 and breast cancer: Of the most frequently mutated genes recently identified in breast cancer in general (41) and TNBC in particular (39) (Tp53, Pik3ca, Myc, Ccnd1, Pten, Erbb2, Znf703/Fgfr1 locus, Gata3, RB1, and Map3k1, Egfr), we only identified mutations in Trp53 (frameshift insertion of “A”) and Pik3cg (synonymous SNV) which is the catalytic subunit of class I PI3 kinases (similar to Pik3ca).